Monday, November 14, 2011

Mitochondria and Brain Disease

Mitochondria and Brain Disease is a great article for anyone looking for the link between the two.

"It is not surprising that, in adult neurons, which depend primarily on ATP production to meet bioenergetic demands, any compromises in mitochondrial function place neurons at a high risk for both dysfunction and/or death. The association between mitochondrial abnormalities and disease has been known for approximately four decades, with the description of a patient with hypermetabolism and a skeletal muscle biopsy demonstrating large numbers of abnormal mitochondria, a disorder now termed “mitochondrial myopathy” (Cassarino & Bennett, 1999). There exists substantial evidence that mitochondrial dysfunction and oxidative damage may play a key role in the pathogenesis of neurodegenerative disease. Evidence implicating both mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer’s disease (AD), and Huntington’s disease (HD), as well as ischemia and other neurological disorders, continues to accumulate"  

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