Monday, November 28, 2011

Mito Cocktail - Quinine

Here is what America's Compounding Center says about Quinine:

"Quinine, which is derived from the herb Cinchona succirubra, was historically applied topically to treat hemorroids and varicose veins. It can be prescribed by a doctor as the doctor as the brand-name medication Qualaquin to treat malaria and the tick-borne illness babesiosis. It is also taken by patients to prevent or treat nighttime leg cramps, and can be used to alleviate leg and muscle cramps in patients with mitochondrial disease. Quinine is taken at low doses of 200-300 mg once every evening for leg cramps, but is used in higher doses for the treatment of malaria and babesiosis. Quinine can cause serious side effects, including a condition called cinchonism, which may result in severe headaches, abdominal discomfort, convulsions, and vision problems. Quinine can also cause severe allergic reactions, hearing problems and ringing in the ears, fever, chills, blood abnormalities, confusion, dizziness, changes in heart rate and/or rhythm, jaundice, and kidney or liver problems."

Thursday, November 17, 2011

Mito Cocktail - Magnesium Orotate

America's Compounding Center says the following about Magnesium Orotate:

"Magnesium orotate is a naturaly occurring substance involved in DNA synthesis, maintaining healthy heart function, and in producing energy for the body's cells. Magnesium orotate may be used to treat magnesium deficiency, improve exercise performance, and improve heart function in patients with cardiovascular disease. Dietary sources of magnesium orotate include root vegetables and whey. Typical dosing for magnesium orotate ranges from 500 - 2,000 mg twice daily, to be taken before meals. Magnesium orotate supplementation is generally well-tolerates, but patients may experience diarrhea."

Mito Cocktail - Uridine

America's Compounding Center says the following about Uridine:

"Uridine is naturally present in the body and is a component of RNA whichis used to produce DNA. Urisine is also involved in the breakdown of carbohydrates to produce energy. Some patients with mitochondrial diseases cannot produce uridine. A recent clinical trial has reported that uridine supplementation may improve cognition, muscle control, and kidney function in children with mitochondrial disease and was generally well-tolerated over a period of two years. The ideal dose of uridine for patients with mitochondrial disease is currently unknown. Long-term therapy with 150 mg of uridine daily has been reported as safe. Uridine supplementation may cause stomach discomfort and diarrhea."

Mito Cocktail - Ribose

America's Compounding Center says the following about Ribose: 

"Ribose is a sugar that is produced by the body from food as a source of energy. Ribose may be effective at increasing energy levels, improving ath;etic performance, improving functionality in patients with coronary artery disease, fibromyalgia, and congestive heart failure, and to prevent symptoms associated with the mitochondrial disease moadenylate deaminase (MAD) deficiency (also known as AMPD deficiency) after exercise, such as muscle pain and cramping. Ribose is usually given as a 15g oral dose four times daily, but can also be given before, during, and after exercise to prevent muscle cramping. Side effects of ribose include stomach discomfort, nausea, diarrhea, headache, and hypoglycemia."